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Effects of resistance training combined with creatine supplementation on muscle strength, physical function, and muscle mass in older adults: a systematic review and three-level meta-analysis

Lingzi Yao, Doudou Yang, Jiajia Gao
Front Nutr 2026 13:1919884

Bibliography

PubMed
PMID 42712402
PubMed Central
PMC13549873
Funding
Authors declared that financial support was not received for the work and/or its publication.
Competing interests
Authors declared no commercial or financial relationships that could be construed as a potential conflict.

Study snapshot

DesignSystematic review and three-level meta-analysis of randomized controlled trials
ModelHuman
Sample11 randomized controlled trials
InterventionCreatine plus resistance training versus resistance training alone or placebo plus resistance training
DurationVaried by included trial
EndpointsMuscle strength; Muscle mass; Physical function

What the study showed, in plain terms

Up-to-date synthesis of whether creatine adds benefit to resistance training in adults aged 60 years and older.

Key findings

Creatine plus resistance training produced a small improvement in muscle strength with moderate-certainty evidence. Additional effects on muscle mass and physical function were not statistically significant and had lower certainty.

What this study can and cannot tell us

Findings were from generally healthy older adults and should not be directly extrapolated to frail or sarcopenic populations; only 11 trials were available.

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