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The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis

Chen Xu, Siyuan Bi, Wenxin Zhang, Lin Luo
Front Nutr 2024 11:1424972

Bibliography

PubMed
PMID 39070254
PubMed Central
PMC11275561
Funding
Funded by the National Natural Science Foundation of China (Project No. 72364006).
Competing interests
Authors declared no commercial or financial relationships that could be construed as a potential conflict.

Study snapshot

DesignSystematic review and meta-analysis of randomized controlled trials
ModelHuman
Sample16 randomized controlled trials; approximately 492 participants
InterventionCreatine monohydrate supplementation versus placebo/control
DurationVaried by included trial
EndpointsOverall cognition; Memory; Executive function; Attention; Information-processing speed

What the study showed, in plain terms

Meta-analysis of adult randomized trials evaluating whether creatine affects multiple cognitive domains.

Key findings

The synthesis reported benefits for memory and some attention/processing-speed measures, while evidence for overall cognition and executive function was less convincing and certainty varied by outcome.

What this study can and cannot tell us

Small trials, heterogeneous dosing and cognitive tests, and low-to-moderate certainty for several domains; findings conflict with other systematic reviews.

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