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Creatine Supplementation and Acute Sleep Deprivation: A Systematic Review of Cognitive, Psychomotor, and Mood Outcomes

Nicholas B Williams, Rachel B Hurley, Manuel E Cevallos
J Integr Complement Med 2026 Online ahead of print:27683605261456529

Bibliography

PubMed
PMID 42261581
DOI
10.1177/27683605261456529
Funding
No explicit funding statement was located in the accessible PubMed or publisher records during Biohack Blueprint's 2026-10-02 audit. This is an audit-status statement, not confirmation that the study received no funding.
Competing interests
No explicit competing-interests statement was located in the accessible PubMed or publisher records during Biohack Blueprint's 2026-10-02 audit. This is an audit-status statement, not confirmation that no competing interests existed.

Study snapshot

DesignSystematic review with narrative synthesis
ModelHuman
Sample5 included studies from 160 screened records
InterventionCreatine supplementation during acute sleep-deprivation paradigms
DurationAcute sleep-deprivation studies
EndpointsCognition; Psychomotor performance; Mood

What the study showed, in plain terms

Systematic review of human studies asking whether creatine can reduce cognitive, psychomotor or mood deterioration during acute sleep loss.

Key findings

The small literature showed a generally favorable trend for selected cognitive outcomes, but effects varied by domain and the evidence base remained sparse.

What this study can and cannot tell us

Only five studies met inclusion criteria, preventing strong quantitative conclusions and leaving dose, timing and population questions unresolved.

Citation network

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction