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Effects of Creatine Supplementation and Resistance Training on Muscle Strength Gains in Adults <50 Years of Age: A Systematic Review and Meta-Analysis

Ziyu Wang, Bopeng Qiu, Ruoling Li, Yunzhi Han, Carl Petersen, Shuting Liu, Yinkai Zhang, Chang Liu, Darren G Candow, Juan Del Coso
Nutrients 2024 16(21):3665

Bibliography

PubMed
PMID 39519498
PubMed Central
PMC11547435
Funding
This research received no external funding.
Competing interests
Darren G. Candow disclosed industry-sponsored creatine research, creatine donations, travel support, advisory-board roles with Alzchem and Create, and expert-witness/consulting work. The authors otherwise declared no conflict of interest.

Study snapshot

DesignSystematic review and meta-analysis
ModelHuman
Sample23 studies; approximately 509 participants described across sex-specific study counts
InterventionCreatine supplementation plus resistance training versus placebo plus resistance training
DurationVaried by included study
EndpointsUpper-body strength; Lower-body strength; Training duration and participant moderators

What the study showed, in plain terms

Age-specific meta-analysis quantifying the added strength effect of creatine during resistance training in adults younger than 50.

Key findings

Creatine plus resistance training significantly improved pooled upper- and lower-body strength compared with placebo plus training.

What this study can and cannot tell us

Most included participants were male and study protocols varied in dose, training status and intervention duration.

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