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Does Creatine Supplementation Enhance Performance in Active Females? A Systematic Review

Ryan Tam, Lachlan Mitchell, Adrienne Forsyth
Nutrients 2025 17(2):238

Bibliography

PubMed
PMID 39861368
PubMed Central
PMC11767391
DOI
10.3390/nu17020238
Funding
The authors reported no external funding.
Competing interests
Authors declared no conflicts of interest.

Study snapshot

DesignSystematic review
ModelHuman
Sample27 studies
InterventionCreatine supplementation in physically active female participants
Duration5 days to 12 weeks across included studies
EndpointsStrength and power; Anaerobic performance; Aerobic performance

What the study showed, in plain terms

Female-specific review of exercise-performance research, useful for separating strong general creatine evidence from the smaller evidence base in active women.

Key findings

Most included studies did not show a performance improvement versus placebo; positive findings appeared in a minority of strength/power, anaerobic and aerobic outcomes. Heterogeneity and limited female-specific methodology constrained conclusions.

What this study can and cannot tell us

Small, heterogeneous female evidence base with variable athlete level, protocols and outcome tests; menstrual and other female-specific methodological factors were often poorly controlled.

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Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology