Tier 3 — preclinical
Sirt6 reprograms myofibers to oxidative type through CREB-dependent Sox6 suppression
Nature Communications
2022
13(1):1808
Bibliography
- PubMed
- PMID 35379817
- PubMed Central
- PMC8980083
- Funding
- Supported by the Medical Research Center Program (2017R1A5A2015061) and Basic Science Research Program grants 2016R1D1A1B01015213, 2020R1A2C2004761 and 2021R1A2B5B02001462 through the National Research Foundation of Korea.
- Competing interests
- The authors declared no competing interests.
Study snapshot
| Design | Integrated mouse genetics, pharmacologic SIRT6 activation, skeletal-muscle phenotyping and human exercise-associated expression analysis. |
|---|---|
| Model | SIRT6 muscle knockout/transgenic mice, activator-treated mice and chronically exercised human muscle observations. |
| Sample | Multiple experimental cohorts; sample sizes vary by experiment. |
| Intervention | Genetic SIRT6 modulation and a pharmacologic SIRT6 activator in mice. |
| Duration | Experiment-dependent. |
| Endpoints | Oxidative myofiber composition; mitochondrial oxidative capacity; exercise endurance; CREB/Sox6 signaling; human SIRT6 expression after chronic exercise |
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