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Creatine in women's health: bridging the gap from menstruation through pregnancy to menopause

Abbie E Smith-Ryan, Gabrielle M DelBiondo, Ann F Brown, Susan M Kleiner, Nhi T Tran, Stacey J Ellery
J Int Soc Sports Nutr 2025 22(1):2502094

Bibliography

PubMed
PMID 40371844
PubMed Central
PMC12086928
Funding
Alzchem supported publication costs for this preconference paper aligned with the Creatine for Health conference 2025.
Competing interests
Abbie Smith-Ryan serves as a scientific advisor for Alzchem and Create Wellness; Stacey Ellery serves as a scientific advisor for Alzchem.

Study snapshot

DesignNarrative review
ModelHuman
SampleReview across female life stages
InterventionCreatine supplementation evidence across menstruation, pregnancy and menopause
DurationNot applicable
EndpointsCreatine metabolism; Exercise performance; Cognition; Reproductive health; Healthy aging

What the study showed, in plain terms

Life-stage review summarizing how hormonal and physiological differences may affect creatine metabolism and the evidence relevant to women.

Key findings

The review identifies plausible and emerging applications across female life stages while emphasizing that women remain underrepresented in creatine research and that pregnancy and reproductive-health evidence is especially incomplete.

What this study can and cannot tell us

Narrative review rather than a pooled efficacy analysis; much of the pregnancy and life-stage evidence is mechanistic, observational or preclinical.

Citation network

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Editorial review

Reviewed by the Biohack Blueprint research team

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