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Creatine monohydrate improved cycling Wingate performance but not cognitive function in young active males and females

João Vitor Silva, Tamires Nunes Oliveira, Priscilla Sampaio, Odara Maria de Sousa Sá, Gabriel Barreto, Hamilton Roschel, Bryan Saunders
Res Sports Med 2026 34(5):575-589

Bibliography

PubMed
PMID 41960895
Funding
Several investigators reported personal research grants from CNPq and the São Paulo Research Foundation (FAPESP).
Competing interests
Bryan Saunders and Hamilton Roschel previously received creatine and placebo supplements from Alzchem free of charge for research; the company was reported to have no role in study design, data collection, analysis or interpretation.

Study snapshot

DesignParallel-group placebo-controlled supplementation trial
ModelHuman
Sample40 healthy physically active adults (20 men, 20 women)
Intervention20 g/day creatine monohydrate or maltodextrin placebo for 7 days
Duration7 days
EndpointsWingate mean power; Wingate peak power; Stroop tests; Trail-making tests

What the study showed, in plain terms

Mixed-sex human trial asking whether one week of creatine loading affects explosive cycling performance and cognition before and after intense exercise.

Key findings

Creatine improved Wingate mean and peak power with no detected sex difference, but did not improve the cognitive tasks measured.

What this study can and cannot tell us

Small sample, short loading period and learning effects in several cognitive tests may have limited detection of cognitive changes; performance results are specific to a 30-second Wingate task.

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