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Effect of L-Arginine Supplementation on Blood Pressure in Adults: A Systematic Review and Dose-Response Meta-analysis of Randomized Clinical Trials

Farideh Shiraseb, Omid Asbaghi, Reza Bagheri, Alexei Wong, Arturo Figueroa, Khadijeh Mirzaei
Advances in Nutrition 2022 13(4):1226–1242

Bibliography

PubMed
PMID 34967840
PubMed Central
PMC9340976
Funding
Not yet independently verified for this record
Competing interests
Not yet independently verified for this record

Study snapshot

DesignSystematic review and dose-response meta-analysis
ModelAdults receiving oral L-arginine in randomized clinical trials (22 trials; 30 effect sizes)
Sample22 randomized trials; 30 effect sizes
InterventionAdults receiving oral L-arginine versus placebo for at least four days
DurationAt least four days per trial; varied among included trials
EndpointsSystolic and diastolic blood pressure

What the study showed, in plain terms

Pooled systolic BP -6.40 mmHg (95% CI -8.74 to -4.05) and diastolic BP -2.64 mmHg (95% CI -3.94 to -1.40).

Key findings

Pooled systolic BP -6.40 mmHg (95% CI -8.74 to -4.05) and diastolic BP -2.64 mmHg (95% CI -3.94 to -1.40).

What this study can and cannot tell us

Population and dosing heterogeneity; these estimates do not apply to arbitrary multi-ingredient products.

Citation network

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Editorial review

Reviewed by the Biohack Blueprint research team

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