Tier 1 — highest

Impact of creatine supplementation and exercise training in older adults: a systematic review and meta-analysis

Ghazal Sharifian, Parastou Aseminia, Diako Heidary, Joseph I Esformes
Eur Rev Aging Phys Act 2025 22(1):17

Bibliography

PubMed
PMID 41062952
PubMed Central
PMC12506341
Funding
The study received no funding.
Competing interests
Authors declared no competing interests.

Study snapshot

DesignSystematic review and meta-analysis
ModelHuman
Sample20 articles; 1,093 participants (69% female)
InterventionCreatine supplementation plus exercise training versus placebo/control plus exercise
DurationVaried by included trial
EndpointsOne-repetition maximum strength; Fat percentage; Bone mineral density; Functional performance; Body composition

What the study showed, in plain terms

Large older-adult synthesis examining whether creatine adds benefit to exercise training across strength, body composition and bone outcomes.

Key findings

Creatine plus exercise improved pooled 1RM strength and modestly reduced fat percentage; total-body bone mineral density was not significantly improved.

What this study can and cannot tell us

Included studies differed in training programs, doses and populations; pooled results do not imply equal benefit for every older adult.

Citation network

Articles citing this research paper

3 articles

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified