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Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism
British Journal of Clinical Pharmacology
2008
65(1):51–59
Bibliography
- PubMed
- PMID 17662090
- PubMed Central
- PMC2291275
- Funding
- Not yet independently verified in full text
- Competing interests
- Not yet independently verified in full text
Study snapshot
| Design | Double-blind randomized placebo-controlled crossover pharmacokinetic study |
|---|---|
| Model | Healthy adult volunteers |
| Sample | 20 healthy volunteers |
| Intervention | Several one-week dosing schedules of oral L-citrulline, sustained-release L-arginine and immediate-release L-arginine |
| Duration | One week per schedule |
| Endpoints | Plasma L-arginine exposure; Plasma L-citrulline exposure; Nitrate excretion; Urinary cGMP; Flow-mediated dilation |
What the study showed, in plain terms
Key findings
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