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Impact of creatine supplementation alone or combined with exercise on inflammatory and clinical outcomes in chronic musculoskeletal pain treated in the rheumatological field: a systematic review

Joaquín Salazar-Méndez, Rodrigo Núñez-Cortés, Cristian Salazar-Orellana, Luis Suso-Martí, Joaquín Calatayud, Iván Cuyul-Vásquez, Katherine Pizarro-Corbalán, Felipe Ponce-Fuentes
Nutrition 2026 150:113330

Bibliography

PubMed
PMID 42407202
Funding
No explicit funding statement was located in the accessible PubMed and publisher abstract records during the 2026-10-02 audit.
Competing interests
Authors declared no known competing financial interests or personal relationships that could have influenced the work.

Study snapshot

DesignSystematic review of randomized and nonrandomized clinical trials
ModelHuman
Sample8 studies; 189 participants
InterventionCreatine alone or with exercise versus control/placebo in fibromyalgia, osteoarthritis, rheumatoid arthritis or juvenile idiopathic arthritis
DurationVaried by included study
EndpointsPain; Physical function; Quality of life; Muscle strength; Skeletal muscle mass; Inflammatory markers

What the study showed, in plain terms

2026 systematic review evaluating creatine as an adjunct in chronic musculoskeletal pain and rheumatologic populations.

Key findings

Creatine combined with exercise showed potential benefits for strength, muscle mass and selected quality-of-life outcomes in some conditions, while effects on pain and inflammation were inconsistent.

What this study can and cannot tell us

Only eight small heterogeneous studies across several different diseases; evidence is insufficient for disease-treatment claims and benefits may depend on concurrent exercise.

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