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Evaluating the Safety of Creatine Monohydrate in Adolescents: A Systematic Review of Renal, Hepatic, and Cardiometabolic Outcomes

Allen Rubinchuk, Zachariah Dulkoski, Nadiya A Persaud, Michelle Wallen

Cureus 2026 18(4):e106808

Bibliography

PubMed: PMID 42124755
PubMed Central: PMC13158627
DOI: 10.7759/cureus.106808
Funding: Authors declared no financial support was received for the submitted work.
Competing interests: Authors declared no financial relationships or other relationships that could appear to have influenced the work.

Study snapshot

Design	Systematic review of human studies
Model	Human
Sample	5 included studies
Intervention	Creatine monohydrate in adolescents or physically active youth
Duration	Varied; studies published 2015–2025
Endpoints	Renal safety; Liver enzymes; Cardiometabolic markers; Serious adverse events

What the study showed, in plain terms

2026 review of the limited human safety literature for creatine monohydrate in adolescents and active youth.

Key findings

Available studies reported no consistent short-term renal, hepatic or cardiometabolic safety signal and no serious adverse events attributed to creatine.

What this study can and cannot tell us

The evidence base was small, heterogeneous and short term; larger prospective trials with standardized dosing and longer follow-up are needed.

Citation network

Articles citing this research paper

1 article

Biohack Blueprint analyses that reference this study in their evidence base.

Oct 2, 2026 Creatine for Teens: What We Know About Safety, Sports and SupervisionCreatine for teens requires more caution than adult supplementation. See what pediatric reviews show, where evidence is thin and when professional guidance...Read analysis

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified 02 October 2026

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction