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The Potential Role of Arginine Supplements on Erectile Dysfunction: A Systemic Review and Meta-Analysis

Hye Chang Rhim, Min Seo Kim, Young-Jin Park, Woo Suk Choi, Hyoung Keun Park, Hyeong Gon Kim, Aram Kim, Sung Hyun Paick
Journal of Sexual Medicine 2019 16(2):223–234

Bibliography

PubMed
PMID 30770070
DOI
10.1016/j.jsxm.2018.12.002
Funding
Not yet independently verified for this record
Competing interests
Not yet independently verified for this record

Study snapshot

DesignSystematic review and meta-analysis of randomized clinical trials
Model540 men with mild-to-moderate erectile dysfunction across ten randomized trials
SampleTen RCTs; 540 men with mild-to-moderate erectile dysfunction
InterventionL-arginine alone or in combinations compared with placebo or no treatment
DurationVaried doses of 1.5–5 g/day and durations among trials
EndpointsErectile function and International Index of Erectile Function subscales; adverse events

What the study showed, in plain terms

Pooled ED improvement OR 3.37 (95% CI 1.29–8.77); interventions and doses differed substantially.

Key findings

Pooled ED improvement OR 3.37 (95% CI 1.29–8.77); interventions and doses differed substantially.

What this study can and cannot tell us

Includes combination formulations and heterogeneous trials; cannot establish Nitralis efficacy or replace medical diagnosis of ED.

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction