Tier 3 — preclinical

MDL800, an allosteric SIRT6 activator, ameliorates UV-induced skin photoaging by attenuating oxidative stress, DNA damage, and collagen degradation

Shuya Ren, Sijie Zhou, Guocai Xu, Zishuo Chen, Songshan Li, Jun Xian, Yangmeihui Wang, Bin Yang
Journal of Photochemistry and Photobiology B: Biology 2026 284:113567

Bibliography

PubMed
PMID 42748553
DOI
10.1016/j.jphotobiol.2026.113567

Study snapshot

DesignHuman dermal fibroblast experiments plus UV-irradiated mouse skin study.
ModelUVA-treated human dermal fibroblasts and BALB/c mouse dorsal skin.
SampleCell and animal experimental cohorts.
InterventionMDL800 SIRT6 activation; OSS-128167 used in mechanistic inhibition experiments.
DurationRepeated UVA/UV exposure experimental protocol.
EndpointsOxidative stress; DNA damage; H3K9Ac/H3K56Ac; Cellular senescence; Collagen organization; MMP1/MMP3; Lamin B1

What the study showed, in plain terms

MDL800 reduced multiple photoaging-related changes in UVA-exposed human dermal fibroblasts and UV-irradiated mouse skin. SIRT6 inhibition partially weakened selected effects, supporting SIRT6 involvement.

Key findings

MDL800 reduced oxidative stress and DNA-damage markers, improved antioxidant signaling and collagen-related readouts, and reduced photoaging-like skin changes in mice.

What this study can and cannot tell us

Preclinical despite use of human cells; topical/systemic exposure is not equivalent to oral fucoidan; no human skin trial or clinical photoaging outcome.

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability