Tier 3 — preclinical
Natural polyphenols as sirtuin 6 modulators
Scientific Reports
2018
8(1):4163
Bibliography
- PubMed
- PMID 29515203
- PubMed Central
- PMC5841289
- Funding
- Supported by the Intramural Research Program of the National Institute on Aging, NIH; Academy of Finland grant 269341; Orion-Farmos Research Foundation; Saastamoinen Foundation; Finnish Cultural Foundation; and NCI federal funds under contract HHSN261200800001E.
- Competing interests
- The authors declared no competing interests.
Study snapshot
| Design | Biochemical screening, docking and cell-based SIRT6-expression study of flavonoids. |
|---|---|
| Model | Purified SIRT6 assays, histone substrates and Caco-2 cells. |
| Sample | Not applicable; biochemical/cell experiments. |
| Intervention | Multiple natural polyphenols including cyanidin, delphinidin and catechin derivatives. |
| Duration | Assay-dependent. |
| Endpoints | SIRT6 deacetylase activity; activation/inhibition fold change; SIRT6 expression in Caco-2 cells; molecular docking |
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