Tier 3 — preclinical
Brain creatine, estradiol and neurocognitive complaints in perimenopausal women: an exploratory cross-sectional study
Neurosci Lett
2026
880:138616
Bibliography
- PubMed
- PMID 42061673
- Funding
- No explicit funding statement was located in the accessible PubMed or publisher records during Biohack Blueprint's 2026-10-02 audit. This is an audit-status statement, not confirmation that the study received no funding.
- Competing interests
- No explicit competing-interests statement was located in the accessible PubMed or publisher records during Biohack Blueprint's 2026-10-02 audit. This is an audit-status statement, not confirmation that no competing interests existed.
Study snapshot
| Design | Exploratory cross-sectional study |
|---|---|
| Model | Human |
| Sample | 12 healthy perimenopausal women |
| Intervention | No supplementation intervention; brain creatine measured by multi-voxel proton magnetic resonance spectroscopy with serum estradiol and symptom ratings |
| Duration | Cross-sectional |
| Endpoints | Regional brain creatine; Estradiol; Concentration difficulties; Headache severity |
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