Tier 1 — highest

Fetal and neonatal effects of N-acetylcysteine for maternal chorioamnionitis: a systematic review

Fawzia Mohamed Elgharbawy, Mohammad A A Bayoumi, Kenni W Ajele, Bashir A Lwaleed
Front Pediatr 2026 14:1819220

Bibliography

PubMed
PMID 42751421
PubMed Central
PMC13579660
DOI
10.3389/fped.2026.1819220
Funding
Funding disclosure was not located in the indexed record reviewed; consult the source publication for the full funding statement.
Competing interests
Competing-interest disclosure was not located in the indexed record reviewed; consult the source publication for the full declaration.

Study snapshot

DesignSystematic review of human and translational studies
ModelHuman
Sample10 studies; human evidence approximately 143 mother-infant dyads
InterventionAntenatal or intrapartum NAC in maternal chorioamnionitis or intra-amniotic infection/inflammation
DurationPerinatal
EndpointsNeonatal morbidity; Cerebrovascular coupling; BPD; Pharmacokinetics; Neuroprotection

What the study showed, in plain terms

September 2026 systematic review of fetal and neonatal outcomes after maternal NAC exposure in chorioamnionitis.

Key findings

Human studies reported promising neuroprotective and neonatal signals without major safety concerns, but findings were small, heterogeneous and sometimes neutral or negative.

What this study can and cannot tell us

Very small human evidence base mixed with animal studies; insufficient for routine clinical implementation.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology