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Unlocking the potential of antioxidant supplementation with n-acetylcysteine to improve seminal parameters and analysis of its safety: a systematic review and meta-analysis of randomized controlled trials

Syarif Syarif, Moh Anfasa Giffari Makkaraka, Ahmad Taufik Fadillah Zainal, Ponco Birowo, Widi Atmoko
Arch Ital Urol Androl 2025 97(1):13750

Bibliography

PubMed
PMID 40126496
DOI
10.4081/aiua.2025.13750
Funding
Funding disclosure was not located in the indexed record reviewed; consult the source publication for the full funding statement.
Competing interests
Competing-interest disclosure was not located in the indexed record reviewed; consult the source publication for the full declaration.

Study snapshot

DesignSystematic review and meta-analysis of randomized controlled trials
ModelHuman
Sample5 randomized studies
InterventionOral NAC versus placebo/control in male infertility
DurationVaried
EndpointsSemen volume; Sperm concentration; Motility; Morphology; Adverse events

What the study showed, in plain terms

Recent randomized-evidence synthesis examining semen outcomes with NAC in male infertility.

Key findings

Pooled results favored NAC for several semen parameters, with no major safety signal reported in the included trials.

What this study can and cannot tell us

Small number of trials, heterogeneous populations and surrogate semen outcomes; fertility and live-birth effects remain less certain.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology