Tier 1 — highest

Efficacy of N-Acetylcysteine in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis

Isabel Viña, Juan R Viña, Macarena Carranza, Gonzalo Mariscal
Nutrients 2025 17(2):284

Bibliography

PubMed
PMID 39861414
PubMed Central
PMC11768055
DOI
10.3390/nu17020284
Funding
Funding disclosure was not located in the indexed record reviewed; consult the source publication for the full funding statement.
Competing interests
The publication reports commercial employment relevant to IVB Wellness Lab; see the full article disclosure for details.

Study snapshot

DesignSystematic review and meta-analysis
ModelHuman
Sample22 studies; 2,515 participants
InterventionNAC compared with placebo, metformin, clomiphene citrate or other comparators
DurationVaried
EndpointsProgesterone; Endometrial thickness; LH; Estradiol; SHBG; FSH

What the study showed, in plain terms

2025 meta-analysis of reproductive and hormonal outcomes in women with PCOS.

Key findings

NAC was associated with improvements in progesterone and endometrial thickness in pooled analyses, while several other hormone outcomes were not significantly different.

What this study can and cannot tell us

Heterogeneous comparators and trial quality; some authors had commercial employment relevant to wellness services.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology