Tier 2 — strong

N-Acetylcysteine Ineffective in Alleviating Hangover from Binge Drinking: A Clinical Study

Boris Podobnik, Lenart Demšar, Lucija Šarc, Aleš Jerin, Joško Osredkar, Jurij Trontelj, Robert Roškar, Miran Brvar
Toxics 2024 12(8):585

Bibliography

PubMed
PMID 39195687
PubMed Central
PMC11360226
DOI
10.3390/toxics12080585
Funding
Funded by the Slovenian Research Agency (grant P3-0019) and University Medical Centre Ljubljana (grant 20200175).
Competing interests
The authors declared no conflicts of interest.

Study snapshot

DesignRandomized double-blind placebo-controlled study
ModelHuman
Sample40 healthy students
InterventionNAC versus placebo around a controlled binge-drinking session
DurationAcute exposure with next-morning assessment
EndpointsAcute Hangover Severity Scale; Oxidative stress markers; Electrolytes; Enzymes

What the study showed, in plain terms

2024 evidence record examining NAC in alcohol hangover.

Key findings

NAC did not improve hangover symptoms or the measured sodium, urea or 8-OHdG responses versus placebo.

What this study can and cannot tell us

Small young healthy sample and acute laboratory-style drinking context; findings do not address alcohol use disorder.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology