Tier 2 — strong

Effects of N-acetylcysteine on the expressions of UCP1 and factors related to thyroid function in visceral adipose tissue of obese adults: a randomized, double-blind clinical trial

Mohammad Hassan Sohouli, Ghazaleh Eslamian, Seyed Hossein Ardehali, Seyed Ahmad Raeissadat, Ghazaleh Shimi, Katayoun Pourvali, Hamid Zand
Genes Nutr 2024 19:8

Bibliography

PubMed
PMID 38702594
PubMed Central
PMC11069202
DOI
10.1186/s12263-024-00744-7
Funding
No funding.
Competing interests
The authors declared no competing interests.

Study snapshot

DesignRandomized double-blind placebo-controlled trial
ModelHuman
Sample43 adults with obesity; 22 NAC and 21 placebo
InterventionNAC 600 mg/day versus placebo
Duration8 weeks
EndpointsAnthropometrics; UCP1 expression; DIO2; DIO3; Thyroid receptor expression; Serum thyroid hormones

What the study showed, in plain terms

Eight-week randomized trial testing NAC effects on adipose thermogenesis/thyroid-related pathways in adults with obesity.

Key findings

NAC reduced DIO3 gene expression in visceral fat but did not significantly change anthropometric factors or serum thyroid-hormone levels versus placebo.

What this study can and cannot tell us

Small short trial in bariatric-surgery candidates; gene-expression changes do not establish increased energy expenditure or weight loss.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology