Tier 2 — strong

Comparing the effect of adjunctive N-acetylcysteine plus low dose contraceptive with low dose contraceptive alone on recurrence of ovarian endometrioma and chronic pelvic pain after conservative laparoscopic surgery: a randomised clinical trial study

Zahra Asgari, Ashraf Moini, Ali Montazeri, Zahra Tavoli, Ladan Hosseini, Reihaneh Hosseini, Afsaneh Tehranian, Rana Karimi
J Obstet Gynaecol 2022 42(5):1493-1497

Bibliography

PubMed
PMID 34994286
DOI
10.1080/01443615.2021.2006165
Funding
Funding disclosure was not located in the indexed record reviewed; consult the source publication for the full funding statement.
Competing interests
Competing-interest disclosure was not located in the indexed record reviewed; consult the source publication for the full declaration.

Study snapshot

DesignRandomized clinical trial
ModelHuman
Sample100 women after conservative laparoscopic surgery
InterventionNAC plus low-dose contraceptive versus low-dose contraceptive alone
Duration6 months
EndpointsEndometrioma recurrence; Pelvic pain

What the study showed, in plain terms

Direct randomized test of adding NAC after surgery for ovarian endometrioma.

Key findings

Adding NAC did not improve recurrence or pelvic-pain outcomes beyond low-dose contraceptive therapy alone.

What this study can and cannot tell us

Postoperative setting and combination treatment; does not test NAC monotherapy in nonsurgical endometriosis.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology