Tier 3 — preclinical

GlyNAC Supplementation Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Aging Hallmarks, Metabolic Defects, Muscle Strength, Cognitive Decline, and Body Composition: Implications for Healthy Aging

Rajagopal V Sekhar
J Nutr 2021 151(12):3606-3616

Bibliography

PubMed
PMID 34587244
DOI
10.1093/jn/nxab309
Funding
Philanthropic support was provided by the Megan and Richard Weekley Foundation and the Lucia and Louis Brandt Foundation.
Competing interests
The author reported no conflicts of interest.

Study snapshot

DesignNarrative review
ModelHuman
SampleReview of mechanistic and clinical evidence
InterventionGlycine plus NAC
DurationNot applicable
EndpointsHealthy aging mechanisms; Glutathione; Mitochondria; Functional outcomes

What the study showed, in plain terms

Review synthesizing the rationale and early clinical findings behind GlyNAC as an aging intervention.

Key findings

Frames GlyNAC as a glutathione-precursor strategy with multiple proposed downstream effects.

What this study can and cannot tell us

Secondary narrative review heavily dependent on a small underlying clinical literature; not independent proof of benefit.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology