Tier 2 — strong

Effects of N-acetylcysteine, oral glutathione and sublingual glutathione on oxidative stress markers

Bernard Schmitt, Morgane Vicenzi, Catherine Garrel, Frédéric M Denis
Redox Biol 2015 6:198-205

Bibliography

PubMed
PMID 26262996
PubMed Central
PMC4536296
DOI
10.1016/j.redox.2015.07.012
Funding
Funding disclosure was not located in the indexed record reviewed; consult the source publication for the full funding statement.
Competing interests
Competing-interest disclosure was not located in the indexed record reviewed; consult the source publication for the full declaration.

Study snapshot

DesignRandomized crossover human study
ModelHuman
Sample20 volunteers with metabolic syndrome
InterventionNAC, oral glutathione and sublingual glutathione in crossover conditions
DurationCrossover supplementation periods
EndpointsGlutathione status; Oxidative stress biomarkers

What the study showed, in plain terms

Direct human comparison of NAC with oral and sublingual glutathione in people with metabolic syndrome.

Key findings

The study provides comparative biomarker evidence rather than proof that one strategy is clinically superior across populations.

What this study can and cannot tell us

Small crossover sample and biomarker endpoints; formulation and dosing limit generalization.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology