Tier 2 — strong

Effect of N-acetylcysteine infusion on exercise-induced modulation of insulin sensitivity and signaling pathways in human skeletal muscle

Adam J Trewin, Leonidas S Lundell, Ben D Perry, Kim Vikhe Patil, Alexander V Chibalin, Itamar Levinger, Leon R McQuade, Nigel K Stepto
Am J Physiol Endocrinol Metab 2015 309(4):E388-E397

Bibliography

PubMed
PMID 26105008
DOI
10.1152/ajpendo.00605.2014
Funding
Funding disclosure was not located in the indexed record reviewed; consult the source publication for the full funding statement.
Competing interests
Competing-interest disclosure was not located in the indexed record reviewed; consult the source publication for the full declaration.

Study snapshot

DesignRandomized crossover infusion study
ModelHuman
Sample7 healthy active adults
InterventionIntravenous NAC around exercise
DurationAcute exercise experiment
EndpointsInsulin sensitivity; p70S6K signaling; Postexercise metabolism

What the study showed, in plain terms

Small mechanistic study testing whether antioxidant exposure alters normal postexercise metabolic responses.

Key findings

NAC reduced the postexercise increase in insulin sensitivity and blunted selected anabolic signaling responses.

What this study can and cannot tell us

Seven participants and intravenous administration; cannot be directly extrapolated to a 1–2 g oral daily supplement regimen.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology