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Oral and Intravenous Acetylcysteine for Treatment of Acetaminophen Toxicity: A Systematic Review and Meta-analysis

Jody L Green, Kennon J Heard, Kate M Reynolds, Donald Albert
West J Emerg Med 2013 14(3):218-226

Bibliography

PubMed
PMID 23687539
PubMed Central
PMC3656701
DOI
10.5811/westjem.2012.4.6885
Funding
Funding disclosure was not located in the indexed record reviewed; consult the source publication for the full funding statement.
Competing interests
Competing-interest disclosure was not located in the indexed record reviewed; consult the source publication for the full declaration.

Study snapshot

DesignSystematic review and meta-analysis
ModelHuman
Sample16 articles; 5,164 patients
InterventionOral versus intravenous acetylcysteine regimens
DurationAcute poisoning treatment
EndpointsHepatotoxicity; Route of administration; Treatment timing

What the study showed, in plain terms

Evidence synthesis comparing oral and intravenous NAC treatment in acetaminophen poisoning.

Key findings

Hepatotoxicity rates were broadly similar by route, while timing of treatment was a major determinant of outcome.

What this study can and cannot tell us

Mostly nonrandomized route comparisons and heterogeneous treatment timing; not designed to establish supplement safety or efficacy.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology