Tier 2 — strong

Infusion with the antioxidant N-acetylcysteine attenuates early adaptive responses to exercise in human skeletal muscle

A C Petersen, M J McKenna, I Medved, K T Murphy, M J Brown, P Della Gatta, D Cameron-Smith
Acta Physiol (Oxf) 2011 204(3):382-392

Bibliography

PubMed
PMID 21827635
DOI
10.1111/j.1748-1716.2011.02344.x
Funding
Funding disclosure was not located in the indexed record reviewed; consult the source publication for the full funding statement.
Competing interests
Competing-interest disclosure was not located in the indexed record reviewed; consult the source publication for the full declaration.

Study snapshot

DesignHuman controlled exercise study
ModelHuman
SampleHuman skeletal-muscle study
InterventionIntravenous NAC around exercise
DurationAcute exercise and early recovery
EndpointsJNK signaling; MnSOD response; Early exercise-adaptation signaling

What the study showed, in plain terms

Important counterweight to the idea that suppressing oxidative stress is always beneficial around training.

Key findings

NAC attenuated selected early redox-sensitive adaptive responses to exercise, including JNK and MnSOD-related signaling.

What this study can and cannot tell us

Acute intravenous protocol and molecular endpoints; does not prove that typical oral NAC causes long-term training impairment.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology