Tier 2 — strong

Effects of oral N-acetylcysteine on fatigue, critical power, and W' in exercising humans

Sarah D Corn, Thomas J Barstow
Respir Physiol Neurobiol 2011 178(2):261-268

Bibliography

PubMed
PMID 21740986
DOI
10.1016/j.resp.2011.06.020
Funding
Funding disclosure was not located in the indexed record reviewed; consult the source publication for the full funding statement.
Competing interests
Competing-interest disclosure was not located in the indexed record reviewed; consult the source publication for the full declaration.

Study snapshot

DesignRandomized placebo-controlled crossover study
ModelHuman
Sample7 men
InterventionAcute oral NAC before severe-intensity exercise
DurationAcute
EndpointsTime to fatigue; Critical power; W'

What the study showed, in plain terms

Small oral NAC study examining severe-intensity exercise across different workloads.

Key findings

Time to fatigue improved in a specific workload condition rather than showing a universal performance benefit.

What this study can and cannot tell us

Very small sample and acute design; outcome depended on exercise intensity.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology