Tier 2 — strong

Effects of N-acetylcysteine on semen parameters and oxidative/antioxidant status

Halil Ciftci, Ayhan Verit, Murat Savas, Ercan Yeni, Ozcan Erel
Urology 2009 74(1):73-76

Bibliography

PubMed
PMID 19428083
DOI
10.1016/j.urology.2009.02.034
Funding
Funding disclosure was not located in the indexed record reviewed; consult the source publication for the full funding statement.
Competing interests
Competing-interest disclosure was not located in the indexed record reviewed; consult the source publication for the full declaration.

Study snapshot

DesignRandomized placebo-controlled trial
ModelHuman
Sample120 men with idiopathic infertility
InterventionOral NAC 600 mg/day versus placebo
Duration3 months
EndpointsSemen volume; Motility; Viscosity; Sperm count; Morphology; Oxidative stress

What the study showed, in plain terms

Controlled male-infertility trial linking NAC with semen parameters and oxidative status.

Key findings

NAC improved semen volume, motility, viscosity and antioxidant status; sperm count and morphology did not significantly differ.

What this study can and cannot tell us

Single-center idiopathic-infertility population; semen changes are surrogate reproductive outcomes, not live-birth evidence.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology