Tier 1 — highest

Adverse reactions associated with acetylcysteine

E A Sandilands, D N Bateman
Clin Toxicol (Phila) 2009 47(2):81-88

Bibliography

PubMed
PMID 19280424
DOI
10.1080/15563650802665587
Funding
Funding disclosure was not located in the indexed record reviewed; consult the source publication for the full funding statement.
Competing interests
Competing-interest disclosure was not located in the indexed record reviewed; consult the source publication for the full declaration.

Study snapshot

DesignSystematic literature review
ModelHuman
SampleLiterature review of oral and intravenous acetylcysteine reactions
InterventionOral and intravenous acetylcysteine
DurationAcute and clinical-use settings
EndpointsNausea; Anaphylactoid reactions; Bronchospasm; Hypotension; Coagulation effects

What the study showed, in plain terms

Foundational review of NAC adverse reactions, especially in acetaminophen-overdose treatment.

Key findings

Oral use is dominated by gastrointestinal effects, while IV use can cause non-IgE-mediated anaphylactoid reactions; asthma/atopy and low acetaminophen concentrations may increase IV-reaction risk.

What this study can and cannot tell us

Many data derive from high-dose hospital antidote protocols rather than ordinary oral supplement use.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology