Tier 2 — strong

The effect of N-acetylcysteine on blood coagulation and platelet function in patients undergoing open repair of abdominal aortic aneurysm

Tomi T Niemi, Edward Munsterhjelm, Reino Pöyhiä, Marja S Hynninen, Markku T Salmenperä
Blood Coagul Fibrinolysis 2006 17(1):29-34

Bibliography

PubMed
PMID 16607076
DOI
10.1097/01.mbc.0000195922.26950.89
Funding
Funding disclosure was not located in the indexed record reviewed; consult the source publication for the full funding statement.
Competing interests
Competing-interest disclosure was not located in the indexed record reviewed; consult the source publication for the full declaration.

Study snapshot

DesignRandomized double-blind placebo-controlled trial
ModelHuman
Sample20 surgical patients
InterventionIV NAC 150 mg/kg bolus followed by 150 mg/kg over 24 hours versus placebo
DurationPerioperative 24-hour infusion
EndpointsProthrombin time; Thromboelastometry; Platelet aggregation; Blood loss

What the study showed, in plain terms

Human trial demonstrating measurable effects of high-dose IV NAC on coagulation and platelet function.

Key findings

NAC prolonged selected coagulation measures and altered platelet-related parameters during major vascular surgery.

What this study can and cannot tell us

Tiny surgical cohort and high-dose IV exposure; relevance to standard oral supplementation is uncertain.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology