Tier 2 — strong

Validation of two point-of-care tests against standard lab measures of NO in saliva and in serum

Ashwin Modi, Evangelia Morou-Bermudez, Jose Vergara, Rakesh P Patel, Alexandria Nichols, Kaumudi Joshipura
Nitric Oxide 2017 64:16–21

Bibliography

PubMed
PMID 28153714
PubMed Central
PMC5569892
Funding
Not yet independently verified for this record
Competing interests
Not yet independently verified for this record

Study snapshot

DesignCross-sectional validation against laboratory assays
Model20 non-smoking overweight or obese adults, ages 40–65
Sample20 non-smoking overweight or obese adults aged 40–65
InterventionCommercial salivary nitrite test strips compared with lab saliva and serum nitrite/nitrate assays
DurationCross-sectional baseline sample; no long-term supplementation intervention
EndpointsCorrelations with laboratory salivary and systemic nitrate/nitrite measurements

What the study showed, in plain terms

Commercial strips correlated with saliva nitrite but not serum nitrite/nitrate, making them unreliable proxies for circulating nitric oxide.

Key findings

Commercial strips correlated with saliva nitrite but not serum nitrite/nitrate, making them unreliable proxies for circulating nitric oxide.

What this study can and cannot tell us

Small specific sample; validation was for tested strip brands, not direct calibration of the proprietary strips used in Nitralis trial.

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Editorial review

Reviewed by the Biohack Blueprint research team

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