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Creatine and Cognition in Aging: A Systematic Review of Evidence in Older Adults

Samantha Marshall, Alexandra Kitzan, Jasmine Wright, Laura Bocicariu, Lindsay S Nagamatsu
Nutr Rev 2026 84(2):333-344

Bibliography

PubMed
PMID 40971619
PubMed Central
PMC12793482
Funding
The paper reports support from Natural Sciences and Engineering Research Council of Canada grants and the Canada Research Chairs Program.
Competing interests
Authors declared no competing interests.

Study snapshot

DesignSystematic review
ModelHuman
Sample6 studies; 1,542 participants
InterventionCreatine supplementation and/or dietary creatine exposure in adults aged 55 years and older
DurationVaried by included study
EndpointsMemory; Attention; Overall cognition

What the study showed, in plain terms

Systematic review focused specifically on creatine and cognitive outcomes in older adults.

Key findings

Five of six included studies reported a positive relationship with cognition, especially memory and attention, but only two were double-blind supplementation trials and study quality was frequently fair or poor.

What this study can and cannot tell us

Most included evidence was cross-sectional rather than randomized supplementation; only six studies and heterogeneous designs limit causal inference.

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