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Effects of creatine supplementation on exercise performance, physiological outcomes, and body composition in females engaged in exercise or training: a systematic review and multilevel meta-analysis

Yi Lin, Wenfeng Zhu, Banghui Hong
Front Nutr 2026 13:1921827

Bibliography

PubMed
PMID 42761190
PubMed Central
PMC13585749
Funding
Supported by the Key Program of Philosophy and Social Sciences of Guizhou Province, China (Grant No. 22GZZD26).
Competing interests
Authors declared no commercial or financial relationships that could be construed as a potential conflict of interest.

Study snapshot

DesignSystematic review and multilevel random-effects meta-analysis
ModelHuman
Sample34 studies in the systematic review; 21 studies contributed 170 effects from 424 analyzable participants
InterventionCreatine supplementation versus control in females engaged in exercise, sport or structured training
DurationVaried by included study
EndpointsExercise performance; Strength and power; Body composition; Physiological outcomes

What the study showed, in plain terms

2026 female-specific quantitative synthesis of creatine effects across exercise performance, body composition and physiological outcomes.

Key findings

Small positive pooled effects were reported for performance and body-composition domains, but certainty was low or very low and physiological effects were uncertain.

What this study can and cannot tell us

Substantial heterogeneity, correlated outcomes, varied protocols and low or very-low certainty prevent firm sport-specific or outcome-specific conclusions.

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