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The Effects of Creatine Supplementation on Upper- and Lower-Body Strength and Power: A Systematic Review and Meta-Analysis

Fatemeh Kazeminasab, Ali Bahrami Kerchi, Fatemeh Sharafifard, Mahdi Zarreh, Scott C Forbes, Donny M Camera, Charlotte Lanhers, Alexei Wong, Michael Nordvall, Reza Bagheri, Frédéric Dutheil
Nutrients 2025 17(17):2748

Bibliography

PubMed
PMID 40944139
Funding
This research received no external funding.
Competing interests
Scott C. Forbes disclosed prior scientific-advisory work for a creatine company, creatine donations for research, creatine education sales, ISSN sports-nutrition advisory work, and advisory work for Bear Balanced; remaining authors declared no conflicts.

Study snapshot

DesignSystematic review and meta-analysis
ModelHuman
Sample69 studies; 1,937 participants
InterventionCreatine supplementation with exercise or no exercise versus placebo/control
DurationVaried by included trial
EndpointsBench/chest press strength; Squat strength; Leg press; Handgrip; Vertical jump; Wingate peak power

What the study showed, in plain terms

Large synthesis quantifying how creatine affects several strength and power outcomes across adults.

Key findings

Creatine plus resistance training produced small but statistically significant gains in several strength and power outcomes, including bench/chest press, squat, vertical jump and Wingate peak power.

What this study can and cannot tell us

Substantial heterogeneity across populations, protocols and outcomes; not every strength measure improved.

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