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Physiological role for nitrate-reducing oral bacteria in blood pressure control

Vikas Kapil, Syed M A Haydar, Vanessa Pearl, Jon O Lundberg, Eddie Weitzberg, Amrita Ahluwalia
Free Radical Biology and Medicine 2013 55:93–100

Bibliography

PubMed
PMID 23183324
PubMed Central
PMC3605573
Funding
Not yet independently verified for this record
Competing interests
Not yet independently verified for this record

Study snapshot

DesignSeven-day controlled before-after human intervention
Model19 healthy human volunteers
Sample19 healthy adult volunteers
InterventionSeven-day control period followed by seven days of chlorhexidine-based antiseptic mouthwash
DurationSeven-day control period, followed by seven-day chlorhexidine-mouthwash period
EndpointsOral nitrate-reducing capacity; plasma nitrite; clinic/home/ambulatory blood pressure

What the study showed, in plain terms

Mouthwash reduced oral nitrite production about 90% and plasma nitrite 25%; modest blood-pressure elevation was observed.

Key findings

Mouthwash reduced oral nitrite production about 90% and plasma nitrite 25%; modest blood-pressure elevation was observed.

What this study can and cannot tell us

Before-after design without randomized period order; dental use should be discussed with a dental clinician rather than discouraged universally.

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