Tier 4 — mechanistic

The Neuroprotective Role of Fisetin in Different Neurological Diseases: A Systematic Review

Jiang Y, Tang X, Deng P, Jiang C, He Y, Hao D, Yang H
Molecular Neurobiology 2023 60(11):6383-6394

Bibliography

PubMed
PMID 37453993
DOI
10.1007/s12035-023-03469-7
Funding
PubMed lists support from the National Natural Science Foundation of China (grants 82071551 and 81830077) and the Key Research and Development Program in Ningxia Hui Autonomous Region (2022CMG02032).
Competing interests
No competing-interest statement is exposed in the PubMed metadata used for this record.

Study snapshot

DesignSystematic review
ModelNarrative synthesis of preclinical (cell and animal model) fisetin studies across neurological diseases
SampleNot applicable as a participant count — systematic review; the PubMed abstract does not report an included-study total.
InterventionNot applicable — review article
DurationNot applicable — systematic review of prior studies; no original experimental follow-up.
EndpointsNot applicable — review article

What the study showed, in plain terms

This 2023 systematic review summarises preclinical research on fisetin's neuroprotective effects across a range of neurological diseases, describing multiple proposed mechanisms and the breadth of disease models in which benefit has been reported. It does not report new experimental data and does not include human trial data.

Key findings

  • The review summarizes fisetin's proposed neuroprotective mechanisms across neurological disease models, mainly cell and animal experiments.
  • It synthesizes existing preclinical research and reports no new human clinical efficacy results for fisetin.

What this study can and cannot tell us

As a narrative synthesis of existing preclinical literature, this review carries the same limitations as its underlying studies — nearly all cell culture or animal model data, with no independent verification of the individual studies summarised and no human trial evidence.

Citation network

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology