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Creatine Supplementation in Children and Adolescents

Andrew R Jagim, Chad M Kerksick

Nutrients 2021 13(2):664

Bibliography

PubMed: PMID 33670822
PubMed Central: PMC7922146
DOI: 10.3390/nu13020664
Funding: Article-processing charge funded by Alzchem Trostberg GmbH.
Competing interests: Authors reported financial remuneration for preparing and reviewing the paper from the special-issue sponsor Alzchem and disclosed consulting/external-funding and paid-presentation relationships with dietary-ingredient companies.

Study snapshot

Design	Narrative review
Model	Human
Sample	Pediatric and adolescent literature
Intervention	Creatine supplementation in pediatric clinical and athletic populations
Duration	Varied by included study
Endpoints	Safety; Exercise performance; Neuromuscular disease; Metabolic disorders

What the study showed, in plain terms

Review of the much smaller pediatric evidence base, including both clinical uses and adolescent sport supplementation.

Key findings

Creatine has therapeutic rationale and clinical use in selected pediatric disorders, but high-quality efficacy and safety data in healthy adolescent athletes are far less extensive than in adults.

What this study can and cannot tell us

Narrative review with sparse healthy-adolescent trials and limited long-term surveillance; pediatric medical indications should not be generalized to routine sport use.

Citation network

Articles citing this research paper

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Biohack Blueprint analyses that reference this study in their evidence base.

Oct 2, 2026 Creatine for Teens: What We Know About Safety, Sports and SupervisionCreatine for teens requires more caution than adult supplementation. See what pediatric reviews show, where evidence is thin and when professional guidance...Read analysis

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified 02 October 2026

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction