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A buffered form of creatine does not promote greater changes in muscle creatine content, body composition, or training adaptations than creatine monohydrate

Andrew R Jagim, Jonathan M Oliver, Adam Sanchez, Elfego Galvan, James Fluckey, Steven Riechman, Michael Greenwood, Katherine Kelly, Cynthia Meininger, Christopher Rasmussen, Richard B Kreider
J Int Soc Sports Nutr 2012 9(1):43

Bibliography

PubMed
PMID 22971354
PubMed Central
PMC3479057
DOI
10.1186/1550-2783-9-43
Funding
AlzChem AG (Germany) funded the study through a research grant to Texas A&M University.
Competing interests
AlzChem funded the study; investigators stated that they independently collected, analyzed and interpreted the results. Richard B. Kreider disclosed prior institutional research grants, legal/scientific consulting and scientific consulting for Woodbolt International; remaining authors declared no competing interests.

Study snapshot

DesignRandomized controlled supplementation and resistance-training trial
ModelHuman
Sample36 resistance-trained participants completed the study
InterventionBuffered creatine versus creatine monohydrate versus placebo during resistance training
Duration28 days
EndpointsMuscle creatine; Body composition; Strength; Anaerobic capacity; Safety markers

What the study showed, in plain terms

Direct comparison testing whether a buffered creatine formulation produces superior muscle or training outcomes to standard creatine monohydrate.

Key findings

Buffered creatine did not produce greater changes in muscle creatine, body composition or training adaptations than creatine monohydrate.

What this study can and cannot tell us

Short four-week study, relatively small trained sample and one buffered formulation; findings do not test every proprietary alternative form.

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Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction