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Creatine supplementation in young men under resistance versus non-resistance training: a systematic review and meta-analysis of strength, performance, and lean mass

Jinfa Gu, Yan Li, Jialing Xiao, Yu Zhang
Front Nutr 2026 13:1800546

Bibliography

PubMed
PMID 42027564
PubMed Central
PMC13099317
Funding
Authors declared no financial support for the work or publication.
Competing interests
Authors declared no commercial or financial relationships that could be construed as a potential conflict of interest.

Study snapshot

DesignSystematic review and meta-analysis of randomized controlled trials
ModelHuman
Sample37 eligible trials after published correction
InterventionCreatine supplementation versus control in healthy men aged 18–30, analyzed by resistance-training versus non-resistance-training context
DurationVaried by included trial
EndpointsFat-free mass; Lean body mass; Squat 1RM; Leg press 1RM; Wingate peak power; Wingate mean power; Countermovement jump

What the study showed, in plain terms

2026 meta-analysis examining whether resistance-training context changes creatine effects on lean mass, strength and anaerobic performance in young men.

Key findings

Lean-mass gains were concentrated in resistance-training studies; several anaerobic-power and squat-strength outcomes favored creatine. Effects differed by endpoint and heterogeneity was substantial for some outcomes.

What this study can and cannot tell us

Restricted to healthy men aged 18–30. A published correction removed two studies that did not meet the prespecified age criterion; some pooled outcomes retained substantial heterogeneity.

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