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Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans

A L Green, E Hultman, I A Macdonald, D A Sewell, P L Greenhaff
Am J Physiol 1996 271(5 Pt 1):E821-E826

Bibliography

PubMed
PMID 8944667
Funding
No explicit funding statement was located in the accessible PubMed or publisher records during Biohack Blueprint's 2026-10-02 audit. This is an audit-status statement, not confirmation that the study received no funding.
Competing interests
No explicit competing-interests statement was located in the accessible PubMed or publisher records during Biohack Blueprint's 2026-10-02 audit. This is an audit-status statement, not confirmation that no competing interests existed.

Study snapshot

DesignControlled human supplementation study
ModelHuman
Sample24 men
Intervention5 g creatine four times daily, with or without 93 g carbohydrate after each dose
Duration5 days
EndpointsMuscle total creatine; Phosphocreatine; Serum insulin; Urinary creatine

What the study showed, in plain terms

Demonstrated that large carbohydrate co-ingestion can increase skeletal-muscle creatine accumulation during a loading protocol.

Key findings

Muscle total creatine increased in both groups, but the rise was about 60% greater when creatine was paired with a large carbohydrate dose.

What this study can and cannot tell us

Large carbohydrate loads are not necessary for routine supplementation and may not be practical; study involved men and short-term loading.

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