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Single-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance

Ali Gordji-Nejad, Andreas Matusch, Lea Hengstler, Simone Beer, Tina Kroll, Sabine Klein, David Elmenhorst, Andreas Bauer, Alexander Drzezga
Nutrients 2026 18(8):1192

Bibliography

PubMed
PMID 42075005
PubMed Central
PMC13119191
Funding
Expenses for the study and personnel budgets were financed by Forschungszentrum Jülich, Germany.
Competing interests
No explicit competing-interests statement was located in the accessible PubMed or publisher records during Biohack Blueprint's 2026-10-02 audit. This is an audit-status statement, not confirmation that no competing interests existed.

Study snapshot

DesignRandomized placebo-controlled human intervention study
ModelHuman
Sample29 healthy adults
InterventionSingle 0.2 g/kg dose of creatine monohydrate or placebo during 21 hours of sleep deprivation
DurationAcute; 21-hour sleep-deprivation protocol
EndpointsLogical reasoning; Numerical processing; Language processing speed; Psychomotor vigilance

What the study showed, in plain terms

Lower-dose follow-up to the group's earlier high-dose sleep-deprivation experiment, testing whether one 0.2 g/kg creatine dose can reduce cognitive deterioration during prolonged wakefulness.

Key findings

Creatine was associated with less deterioration in logical and numerical tasks, language-related processing speed and psychomotor vigilance, with reported improvements up to about 12%. Female participants showed larger effects in several tasks.

What this study can and cannot tell us

Small acute experiment under sleep deprivation; high single dose compared with routine maintenance; task-specific findings should not be generalized to broad cognitive enhancement in rested adults.

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