Tier 4 — mechanistic

Inflammaging: a new immune-metabolic viewpoint for age-related diseases

Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A
Nature Reviews Endocrinology 2018 14(10):576-590

Bibliography

PubMed
PMID 30046148
DOI
10.1038/s41574-018-0059-4
Funding
Not disclosed in the abstract; not independently verified.
Competing interests
Not disclosed in the abstract; not independently verified.

Study snapshot

DesignNarrative review
ModelN/A - conceptual/theoretical review, no experimental model
SampleNot applicable — narrative review, no original participants.
InterventionN/A - no intervention tested
DurationNot applicable — synthesis of existing research without an intervention.
EndpointsN/A

What the study showed, in plain terms

This review describes 'inflammaging' - the chronic, low-grade, sterile inflammation that develops with age and contributes to many age-related diseases. It proposes that this inflammation is driven by an immune-metabolic process involving cell debris, gut microbiota, and nutrient excess. The paper does not test fisetin or any other specific compound; it is cited here only to explain the general biological concept.

Key findings

  • Inflammaging is chronic, low-grade, often sterile inflammation associated with advancing age.
  • The authors describe interactions among immune activation, metabolism and age-related disease.
  • The review does not test fisetin or establish any fisetin treatment effect.

What this study can and cannot tell us

A narrative review, not a primary study - no new experimental data. Contains no fisetin-specific content; used only to explain the inflammaging concept referenced elsewhere in the article.

Citation network

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology