Tier 1 — highest

Effects of chronic nitrate supplementation on blood pressure in adults: a systematic review and meta-analysis of randomized clinical trials

Daniel Forster, Gustavo Waclawovsky, Giuseppe Potrick Stefani
Nutrition Research 2026 146:111–120

Bibliography

PubMed
PMID 41619653
DOI
10.1016/j.nutres.2025.08.002
Funding
Not yet independently verified in full text
Competing interests
Not yet independently verified in full text

Study snapshot

DesignSystematic review and meta-analysis of placebo-controlled randomized clinical trials
ModelAdults, predominantly older than 50 years
Sample6 randomized trials; 181 participants
InterventionSodium nitrate supplementation of at least one week duration, excluding beetroot juice
DurationAt least one week per included trial
EndpointsSystolic blood pressure; Diastolic blood pressure; Resting heart rate

What the study showed, in plain terms

A 2026 review pooled six chronic sodium-nitrate trials. Its intervention differs from beetroot juice and proprietary multi-ingredient nitric oxide supplements.

Key findings

Six studies involving 181 participants qualified for pooled chronic blood-pressure analysis. Use the original full text for pooled numerical estimates before quoting them.

What this study can and cannot tell us

Only six trials and 181 people; scope excludes beetroot interventions. Numerical pooled outcome not transcribed here because the verified abstract available in this pass was incomplete.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction