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Meta-Analysis Examining the Importance of Creatine Ingestion Strategies on Lean Tissue Mass and Strength in Older Adults

Scott C Forbes, Darren G Candow, Sergej M Ostojic, Michael D Roberts, Philip D Chilibeck
Nutrients 2021 13(6):1912

Bibliography

PubMed
PMID 34199420
PubMed Central
PMC8229907
Funding
This research received no external funding.
Competing interests
Scott Forbes disclosed prior scientific-advisory work for a creatine company. Darren Candow disclosed industry-sponsored creatine research, creatine donations, travel support and AlzChem scientific-advisory-board service. Sergej Ostojic disclosed AlzChem advisory-board service, creatine-related patents and research funding relationships.

Study snapshot

DesignSystematic review and meta-analysis with dosing-strategy subanalyses
ModelHuman
SampleRandomized placebo-controlled resistance-training studies in older adults
InterventionCreatine during resistance training, including ≤5 g/day, >5 g/day, loading and training-day-only strategies
DurationVaried; resistance-training interventions
EndpointsLean tissue mass; Chest-press strength; Leg-press strength; Effects of loading and maintenance strategies

What the study showed, in plain terms

Meta-analysis asking whether creatine dose, loading and supplementation frequency change lean-mass or strength outcomes in older adults.

Key findings

Creatine generally augmented resistance-training gains; subanalyses suggested some strategy-specific strength effects, although patterns changed when loading studies were excluded.

What this study can and cannot tell us

Subgroup analyses contained fewer trials and substantial between-study heterogeneity, so apparent dosing differences should not be treated as definitive head-to-head evidence.

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