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Effects of Creatine Monohydrate on Endurance Performance in a Trained Population: A Systematic Review and Meta-analysis

Julen Fernández-Landa, Asier Santibañez-Gutierrez, Nikola Todorovic, Valdemar Stajer, Sergej M Ostojic

Sports Med 2023 53:1257-1270

Bibliography

PubMed: PMID 36877404
DOI: 10.1007/s40279-023-01823-2
Funding: No explicit funding statement was located in the accessible PubMed or publisher records during Biohack Blueprint's 2026-10-02 audit. This is an audit-status statement, not confirmation that the study received no funding.
Competing interests: No explicit competing-interests statement was located in the accessible PubMed or publisher records during Biohack Blueprint's 2026-10-02 audit. This is an audit-status statement, not confirmation that no competing interests existed.

Design	Systematic review and meta-analysis
Model	Human
Sample	13 placebo-controlled studies
Intervention	Creatine monohydrate supplementation in trained populations
Duration	Varied by included trial
Endpoints	Endurance performance

Focused test of whether creatine's established high-intensity benefits extend to endurance performance.

The pooled analysis found no significant improvement in endurance performance in trained populations.

Only 13 studies, heterogeneous endurance protocols and trained populations; findings do not address repeated sprint or strength-dependent events.

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Last verified 02 October 2026