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Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function, cognitive performance and quality of life in older adults: A randomized, double-blind, placebo-controlled trial
Exp Gerontol
2026
218:113122
Bibliography
- PubMed
- PMID 41941966
- Trial registry
- View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
- Funding
- No explicit funding statement was located in the accessible PubMed or publisher records during Biohack Blueprint's 2026-10-02 audit. This is an audit-status statement, not confirmation that the study received no funding.
- Competing interests
- No explicit competing-interests statement was located in the accessible PubMed or publisher records during Biohack Blueprint's 2026-10-02 audit. This is an audit-status statement, not confirmation that no competing interests existed.
Study snapshot
| Design | Randomized double-blind placebo-controlled multi-arm trial |
|---|---|
| Model | Human |
| Sample | 103 older adults (57 women, 46 men; mean age 68.2 years) |
| Intervention | 3 g/day creatine or placebo with land- or water-based high-load velocity-intentional resistance training, plus creatine/placebo controls |
| Duration | 16 weeks |
| Endpoints | Strength; Physical function; Cognition; BDNF; Oxidative stress; Inflammatory markers; Quality of life |
What the study showed, in plain terms
Key findings
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- Creatine for Muscle Growth: Lean Mass, Hypertrophy and Resistance Training EvidenceCreatine for muscle growth: what meta-analyses show about lean mass, strength, water weight, training volume and whether creatine builds muscle without lifting.Read analysis
- Creatine for Older Adults: Strength, Function, Muscle and Healthy AgingCreatine for older adults: what randomized trials and meta-analyses show about strength, muscle mass, physical function, cognition and practical dosing.Read analysis
- Creatine Benefits: Strength, Muscle, Brain and Healthy Aging EvidenceThe benefits of creatine separated by evidence strength: strength, lean mass, performance, women, older adults and cognition.Read analysis
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