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Acute Responses to Creatine Monohydrate and L-Arginine, Alone and Combined, on Repeated-Sprint Power, Countermovement Jump Height, and Stroop Reaction Time in Recreationally Active Men: A Randomized Double-Blind Crossover Trial

Özgür Eken, Halil Uçar, Ahmet Kurtoğlu, Murat Ozan, Yusuf Buzdağlı, Mehmet Söyler, Monira I Aldhahi

Metabolites 2026 16(9):688

Bibliography

PubMed: PMID 42783813
DOI: 10.3390/metabo16090688
Trial registry: View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding: Supported by Princess Nourah bint Abdulrahman University Researchers Supporting Project PNURSP2026R286.
Competing interests: No explicit competing-interests statement was located in the accessible PubMed or publisher records during Biohack Blueprint's 2026-10-02 audit. This is an audit-status statement, not confirmation that no competing interests existed.

Study snapshot

Design	Randomized double-blind four-period crossover trial
Model	Human
Sample	18 recreationally active men
Intervention	Placebo, creatine monohydrate 0.3 g/kg, L-arginine 6 g, or combined L-arginine plus creatine; testing 60 minutes after ingestion
Duration	Acute crossover sessions
Endpoints	Repeated-sprint average power; Repeated-sprint peak power; Countermovement jump; Stroop reaction time

What the study showed, in plain terms

Very recent acute crossover trial testing whether combining creatine with L-arginine adds performance or cognitive effects beyond either supplement alone.

Key findings

The combined condition improved selected sprint, jump and reaction-time outcomes versus some comparators, but factorial analysis did not establish a statistically robust creatine-by-arginine interaction for the co-primary outcomes.

What this study can and cannot tell us

Small male-only sample, acute design, potential carryover and unmodelled period/sequence effects; results are exploratory and do not establish biological synergy.

Citation network

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1 article

Biohack Blueprint analyses that reference this study in their evidence base.

Oct 2, 2026 Creatine for Strength and Performance: Power, Sprints and Endurance EvidenceCreatine performance evidence separated by outcome: strength, repeated high-intensity work, power, sprinting and why endurance results are much weaker.Read analysis

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified 02 October 2026

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction