Tier 3 — preclinical
SIRT6 regulates metabolic homeostasis in skeletal muscle through activation of AMPK
American Journal of Physiology-Endocrinology and Metabolism
2017
313(4):E493-E505
Bibliography
- PubMed
- PMID 28765271
- Funding
- Funding indexed for this publication includes National Natural Science Foundation of China support.
- Competing interests
- No competing-interest statement was identified in the accessible publication record.
Study snapshot
| Design | Muscle-specific SIRT6 knockout study with metabolic and exercise-performance phenotyping. |
|---|---|
| Model | Genetically modified mice and muscle-cell experiments. |
| Sample | Preclinical experiments; endpoint-specific sample sizes reported in the paper. |
| Intervention | Muscle-specific SIRT6 deletion with AMPK-pathway analyses. |
| Duration | Experiment-dependent. |
| Endpoints | Glucose homeostasis; insulin sensitivity; energy expenditure; exercise performance; AMPK activity; mitochondrial and fuel-use gene expression |
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- SIRT6, Muscle & Exercise: AMPK, Oxidative Fibers and Human EvidenceSIRT6 supports muscle metabolism, AMPK and oxidative fibers in animal studies. See human exercise associations, activator data and what performance claims remain...Read analysis
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